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Nepafenac is , while it's Molecular Formula is C15H14N2O2. Nepafenac is a non-steroidal anti-inflammatory drug (NSAID), usually sold as a prescription eye drop. It reduces pain and inflammation in the eyes. Nepafenac ophthalmic is used to reduce pain and swelling after cataract surgery.
The CAS number of Nepafenac is 78281-72-8.
More information of Nepafenac 78281-72-8 are:
Synonyms |
Benzoic acid,3-fluoro-2-iodo-;AHR 9434;AL 6515;Nevanac; |
CAS Number |
78281-72-8 |
Molecular Formula |
C15H14N2O2 |
Molecular Weight |
254.288 |
Density |
1.249 g/cm3 |
Melting Point |
177-181oC |
Boiling Point |
562.5 °C at 760 mmHg |
Flash Point |
294 °C |
HS CODE |
2924299090 |
PSA |
86.18000 |
LogP |
2.80910 |
Nepafenac, launched by Alcon Laboratories, is a topical ophthalmic medication indicated for the treatment of ocular pain and inflammation associated with cataract surgery. Nepafenac is a prodrug of amfenac, which is an NSAID and a potent non-selective inhibitor of COX-1 (IC50=0.25 μM)) and COX-2 (IC50=0.15μM). Nepefenac itself exhibits only weak activity against COX-1 (IC50=64.3μM). Amfenac (Fenazox) has been marketed in Japan since 1986 for the treatment of rheumatoid arthritis, post-surgical pain, and inflammation. With most NSAIDs that are currently being used as topical ophthalmic agents, the maximum drug concentration is achieved on the ocular surface, with progressively lower concentrations in the cornea, aqueous humor, vitreous, and retina. Nepafenac has been found to have a penetration coefficient that is 4-28 times greater than that achieved with conventional NSAIDs such as diclofenac, bromofenac, and ketorolac. In addition, the bioconversion of nepefenac to amfenac is primarily mediated by ocular tissue hydrolases, specifically in the iris, ciliary body, retina, and choroid. The enhanced permeability of nepefenac combined with rapid bioactivation in the ocular tissue translates into superior anti-inflammatory efficacy at the target sites.
InChI:InChI=1/C15H14N2O2/c16-13(18)9-11-7-4-8-12(14(11)17)15(19)10-5-2-1-3-6-10/h1-8H,9,17H2,(H2,16,18)
Articles related to Nepafenac:
Article |
Source |
Preparation method of nepafenac |
- Paragraph 0039; 0047; 0054; 0055, (2017/09/01) |
Development and a practical synthesis of nepafenac intermediate via modified gassman reaction |
Cybulski, Marcin,Formela, Adam,Mucha, Mariola,Klos, Karolina,Roszczynski, Jacek,Winiarski, Jerzy , p. 461 - 464,4 (2020/08/24) |
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