78281-72-8

  • Product NameNepafenac
  • Molecular FormulaC15H14N2O2
  • Molecular Weight254.288
  • Purity99%
Inquiry

Product Details

Quick Details

  • CasNo: 78281-72-8
  • Molecular Formula: C15H14N2O2
  • Purity: 99%

China cas 78281-72-8 manufacturer wholesale Nepafenac at affordable price We supply high quality Nepafenac (CAS 78281-72-8), in stock, factory directly supply to clients, lower prices, more competitiveness.

What is the Nepafenac ?

Nepafenac is , while it's Molecular Formula is C15H14N2O2. Nepafenac is a non-steroidal anti-inflammatory drug (NSAID), usually sold as a prescription eye drop. It reduces pain and inflammation in the eyes. Nepafenac ophthalmic is used to reduce pain and swelling after cataract surgery.

What is the CAS number for Nepafenac ?

The CAS number of Nepafenac is 78281-72-8.

More information of Nepafenac 78281-72-8 are:

Synonyms

Benzoic acid,3-fluoro-2-iodo-;AHR 9434;AL 6515;Nevanac;

CAS Number

78281-72-8

Molecular Formula

C15H14N2O2

Molecular Weight

254.288

Density

1.249 g/cm3

Melting Point

177-181oC

Boiling Point

562.5 °C at 760 mmHg

Flash Point

294 °C

HS CODE

2924299090

PSA

86.18000

LogP

2.80910

What is Nepafenac (78281-72-8) used for?

Nepafenac, launched by Alcon Laboratories, is a topical ophthalmic medication indicated for the treatment of ocular pain and inflammation associated with cataract surgery. Nepafenac is a prodrug of amfenac, which is an NSAID and a potent non-selective inhibitor of COX-1 (IC50=0.25 μM)) and COX-2 (IC50=0.15μM). Nepefenac itself exhibits only weak activity against COX-1 (IC50=64.3μM). Amfenac (Fenazox) has been marketed in Japan since 1986 for the treatment of rheumatoid arthritis, post-surgical pain, and inflammation. With most NSAIDs that are currently being used as topical ophthalmic agents, the maximum drug concentration is achieved on the ocular surface, with progressively lower concentrations in the cornea, aqueous humor, vitreous, and retina. Nepafenac has been found to have a penetration coefficient that is 4-28 times greater than that achieved with conventional NSAIDs such as diclofenac, bromofenac, and ketorolac. In addition, the bioconversion of nepefenac to amfenac is primarily mediated by ocular tissue hydrolases, specifically in the iris, ciliary body, retina, and choroid. The enhanced permeability of nepefenac combined with rapid bioactivation in the ocular tissue translates into superior anti-inflammatory efficacy at the target sites.

InChI:InChI=1/C15H14N2O2/c16-13(18)9-11-7-4-8-12(14(11)17)15(19)10-5-2-1-3-6-10/h1-8H,9,17H2,(H2,16,18)

Articles related to Nepafenac:

Article

Source

Preparation method of nepafenac

-

Paragraph 0039; 0047; 0054; 0055, (2017/09/01)

Development and a practical synthesis of nepafenac intermediate via modified gassman reaction

Cybulski, Marcin,Formela, Adam,Mucha, Mariola,Klos, Karolina,Roszczynski, Jacek,Winiarski, Jerzy

, p. 461 - 464,4 (2020/08/24)

How to get the best price on Nepafenac?

Tianjin Rad Chem Tech Co., LTD. is a quality supplier and manufacturer of Nepafenac . You can buy high quality, low price Nepafenac 78281-72-8 here. Contact us.

;
*Product Name
CasNo
Quantity
Company Name
Phone
*Email
*Description
*Code
Items marked with * are mandatory
Submit