What is the 4-Methylbenzophenone?

4-Methylbenzophenone is white to slightly yellow powder, while it's Molecular Formula is C14H12O. white to slightly yellow powder 4-Methylbenzophenone may be used as a reference standard for the determination of the analyte in breakfast cereals, paperboard food packaging and packed milk by various chromatography techniques.

What is the CAS number for 4-Methylbenzophenone?

The CAS number of 4-Methylbenzophenone is 134-84-9.

What is 4-Methylbenzophenone (134-84-9) used for?

4-Methylbenzophenone is a white to beige crystalline powder or crystals, known for its photo-initiating properties in the printing industry. It is also recognized for its estrogenic and toxic effects, which have been studied in relation to its chemical structure and activity.InChI:InChI=1/C14H18O/c1-11-7-9-13(10-8-11)14(15)12-5-3-2-4-6-12/h7-10,12H,2-6H2,1H3

Chemical plants supply high-quality 4-methylbenzophenone 134-84-9 in bulk

Product Details

Quick Details

CasNo： 134-84-9
Molecular Formula： C₁₄H₁₂O
Appearance： white to slightly yellow powder
Purity： 99%

Chemical plants supply high-quality 4-methylbenzophenone 134-84-9 in bulk

Molecular Formula:C14H12O
Molecular Weight:196.249
Appearance/Colour:white to slightly yellow powder
Vapor Pressure:0.000413mmHg at 25°C
Melting Point:56.5-57 ºC
Refractive Index:1.534
Boiling Point:328.1 ºC at 760 mmHg
Flash Point:141 ºC
PSA：17.07000
Density:1.067 g/cm³
LogP:3.22600

4-Methylbenzophenone(Cas 134-84-9) Usage

Synthesis Reference(s)	Journal of the American Chemical Society, 82, p. 1223, 1960 DOI: 10.1021/ja01490a047Tetrahedron Letters, 40, p. 3109, 1999 DOI: 10.1016/S0040-4039(99)00476-1Synthesis, p. 776, 1977 DOI: 10.1055/s-1977-24573
Flammability and Explosibility	Notclassified
Safety Profile	Poison by intraperitoneal route. A flammable liquid. When heated to decomposition it emits acrid smoke and irritating fumes.
Purification Methods	Crystallise the ketone from MeOH, Et2O (m 58-59o) or pet ether. The cis-oxime has m 154o(153-156o) (from EtOH), and the trans-oxime has m 114-116o (from pet ether). [Beilstein 7 H 440, 7 III 2127, 7 IV 1403.]
General Description	4-Methylbenzophenone is a photo-initiator for printing inks, mainly applied to the cardboard boxes used for packing. It is reported to be a non-genotoxic carcinogen. However, it can contaminate foodstuffs when it comes in contact with the package contents.

InChI:InChI=1/C14H18O/c1-11-7-9-13(10-8-11)14(15)12-5-3-2-4-6-12/h7-10,12H,2-6H2,1H3

134-84-9 Relevant articles

-

Denney et al.

, p. 46,50 (1964)

Solvent-free C-benzoylation and N-benzoylation reactions using

Al-Masum, Mohammad,Wai, Maya Chen,Dunnenberger, Henry

, p. 2888 - 2898 (2011)

An ecofriendly and efficient microwave-i...

The Most Twisted Acyclic Amides: Structures and Reactivity

Liu, Chengwei,Shi, Shicheng,Liu, Yongmei,Liu, Ruzhang,Lalancette, Roger,Szostak, Roman,Szostak, Michal

, p. 7771 - 7774 (2018)

The synthesis, crystal structures, and r...

Visible-light-driven selective oxidation of alcohols using a dye-sensitized TiO2-polyoxometalate catalyst

Yang, Xue,Zhao, Hui,Feng, Jifei,Chen, Yanning,Gao, Shuiying,Cao, Rong

, p. 59 - 66 (2017)

This study demonstrated a dye-sensitized...

A Simple and Effective Method for Catalytic Oxidation of Alcohols Using the Oxone/Bu4NHSO4 Oxidation System

An, X. Q.,Kang, M.,Ma, H. C.,Yang, Y. X.,Yang, Z. W.,Zeng, W.

, p. 521 - 523 (2020)

Abstract: A simple and efficient procedu...

Synthesis, characterization and antibacterial effect of diarylmethylamine-based imines

K?se, Muhammet,Ko?er, Ferudun,Onur, Sultan,Tümer, Ferhan

, (2020)

Firstly, starting from benzoic acid the ...

-

White et al.

, p. 3613 (1961)

Hypervalent iodine in synthesis part 39. Palladium-catalyzed carbonylative coupling of iodonium salts and potassium aryltrifluoroborates by carbon monoxide

Xia, Min,Chen, Zhenchu

, p. 400 - 401 (1999)

Diaryl ketones and chalcones are obtaine...

Chloramine-T-mediated oxidation of benzylic alcohols using indium(III) triflate

Nakahara, Kazuhide,Kitazawa, Chie,Mineno, Tomoko

, p. 801 - 804 (2017)

The efficient oxidation of benzylic alco...

Direct Formation and Subsequent Substitution of Remote Ketone-Functionalized Organocopper Reagents

Ebert, Greg W.,Klein, Walter R.

, p. 4744 - 4747 (1991)

Remote ketone-functionalized aryl- and a...

Photo-Catalytic oxidation of benzyl alcohols using oxone in the presence of n-Bu4NBr in water

Wu, Shang,Ma, Hengchang,Yan, Penghua,Wang, Jianqiang,Ding, Juanjuan,Lei, Ziqiang

, p. 424 - 427 (2009)

A simple, mild and efficient method has ...

IPr# - highly hindered, broadly applicable N-heterocyclic carbenes

Flach, Carol,Lalancette, Roger,Li, Guangchen,Mendelsohn, Richard,Meng, Guangrong,Szostak, Michal,Szostak, Roman,Zhao, Qun

, p. 10583 - 10589 (2021)

IPr (IPr = 1,3-bis(2,6-diisopropylphenyl...

Palladium-NHC (NHC = N-heterocyclic Carbene)-Catalyzed Suzuki-Miyaura Cross-Coupling of Alkyl Amides

Wang, Chang-An,Rahman, Md. Mahbubur,Bisz, Elwira,Dziuk, B?az?ej,Szostak, Roman,Szostak, Michal

, p. 2426 - 2433 (2022/02/17)

We report the Pd-catalyzed Suzuki-Miyaur...

Selective Activation of Unstrained C(O)-C Bond in Ketone Suzuki-Miyaura Coupling Reaction Enabled by Hydride-Transfer Strategy

Zhong, Jing,Zhou, Wuxin,Yan, Xufei,Xia, Ying,Xiang, Haifeng,Zhou, Xiangge

supporting information, p. 1372 - 1377 (2022/02/23)

A Rh(I)-catalyzed ketone Suzuki-Miyaura ...

Using Data Science To Guide Aryl Bromide Substrate Scope Analysis in a Ni/Photoredox-Catalyzed Cross-Coupling with Acetals as Alcohol-Derived Radical Sources

Doyle, Abigail G.,Gandhi, Shivaani S.,Jiang, Shutian,Kariofillis, Stavros K.,Martinez Alvarado, Jesus I.,?urański, Andrzej M.

supporting information, p. 1045 - 1055 (2022/01/19)

Ni/photoredox catalysis has emerged as a...

Synthesis of biaryl ketones and biaryl diketones via carbonylative Suzuki-Miyaura coupling reactions catalyzed by bridged bis(N-heterocyclic carbene)palladium(II) catalysts

-

Page/Page column 20; 22-26, (2021/12/23)

This disclosure relates to bridged bis(N...

134-84-9 Process route

: 108-88-3,15644-74-3,16713-13-6
toluene

: 134-84-9
4-Methylbenzophenone

: 713-36-0
2-benzyltoluene

: 131-58-8
2-Methylbenzophenone

: 100-52-7
benzaldehyde

Conditions

Conditions	Yield
toluene; at 25 ℃; for 336h; With water; In methanol; for 1h;

: 15106-88-4
di(p-tolyl)zinc

: 98-88-4
benzoyl chloride

: 134-84-9
4-Methylbenzophenone

: 2431-00-7
p-methylbenzil

: 53432-81-8
2-Hydroxy-2-phenyl-1,2-di(p-tolyl)ethanone

: 100-52-7
benzaldehyde

: PhCOC(p-Tol)2(OH)

Conditions

Conditions	Yield
With carbon monoxide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; byproducts: (p-Tol)2CO; High Pressure; 0.5 mmol PhCOCl, 1 mmol (p-Tol)2Zn, 2 mmol MgClBr, 0.05 mmol Pd complex,20 ml THF, CO 30 atm, stirred at 25°C for 16 h; GC-MS, GC;	0% 48% 2% <0.5 <0.5

134-84-9 Upstream products

56-23-5
tetrachloromethane
623-11-0
1-methyl-4-nitrosobenzene
620-83-7
1-methyl-4-(phenylmethyl)benzene
42449-55-8
dichloro-phenyl-p-tolyl-methane

134-84-9 Downstream products

102237-58-1
1-phenyl-2-[2]pyridyl-1-p-tolyl-ethanol
408526-00-1
1,3-diphenyl-1-(p-tolyl)prop-2-yn-1-ol
100337-62-0
1-methyl-4-(1-phenylprop-1-en-1-yl)benzene
48191-15-7
2,4'-dimethyl-trityl chloride

;

134-84-9

Quick Details

Chemical plants supply high-quality 4-methylbenzophenone 134-84-9 in bulk

4-Methylbenzophenone(Cas 134-84-9) Usage

134-84-9 Relevant articles

-

Denney et al.

, p. 46,50 (1964)

Solvent-free C-benzoylation and N-benzoylation reactions using

Al-Masum, Mohammad,Wai, Maya Chen,Dunnenberger, Henry

, p. 2888 - 2898 (2011)

The Most Twisted Acyclic Amides: Structures and Reactivity

Liu, Chengwei,Shi, Shicheng,Liu, Yongmei,Liu, Ruzhang,Lalancette, Roger,Szostak, Roman,Szostak, Michal

, p. 7771 - 7774 (2018)

Visible-light-driven selective oxidation of alcohols using a dye-sensitized TiO2-polyoxometalate catalyst

Yang, Xue,Zhao, Hui,Feng, Jifei,Chen, Yanning,Gao, Shuiying,Cao, Rong

, p. 59 - 66 (2017)

A Simple and Effective Method for Catalytic Oxidation of Alcohols Using the Oxone/Bu4NHSO4 Oxidation System

An, X. Q.,Kang, M.,Ma, H. C.,Yang, Y. X.,Yang, Z. W.,Zeng, W.

, p. 521 - 523 (2020)

Synthesis, characterization and antibacterial effect of diarylmethylamine-based imines

K?se, Muhammet,Ko?er, Ferudun,Onur, Sultan,Tümer, Ferhan

, (2020)

-

White et al.

, p. 3613 (1961)

Hypervalent iodine in synthesis part 39. Palladium-catalyzed carbonylative coupling of iodonium salts and potassium aryltrifluoroborates by carbon monoxide

Xia, Min,Chen, Zhenchu

, p. 400 - 401 (1999)

Chloramine-T-mediated oxidation of benzylic alcohols using indium(III) triflate

Nakahara, Kazuhide,Kitazawa, Chie,Mineno, Tomoko

, p. 801 - 804 (2017)

Direct Formation and Subsequent Substitution of Remote Ketone-Functionalized Organocopper Reagents

Ebert, Greg W.,Klein, Walter R.

, p. 4744 - 4747 (1991)

Photo-Catalytic oxidation of benzyl alcohols using oxone in the presence of n-Bu4NBr in water

Wu, Shang,Ma, Hengchang,Yan, Penghua,Wang, Jianqiang,Ding, Juanjuan,Lei, Ziqiang

, p. 424 - 427 (2009)

IPr# - highly hindered, broadly applicable N-heterocyclic carbenes

Flach, Carol,Lalancette, Roger,Li, Guangchen,Mendelsohn, Richard,Meng, Guangrong,Szostak, Michal,Szostak, Roman,Zhao, Qun

, p. 10583 - 10589 (2021)

Palladium-NHC (NHC = N-heterocyclic Carbene)-Catalyzed Suzuki-Miyaura Cross-Coupling of Alkyl Amides

Wang, Chang-An,Rahman, Md. Mahbubur,Bisz, Elwira,Dziuk, B?az?ej,Szostak, Roman,Szostak, Michal

, p. 2426 - 2433 (2022/02/17)

Selective Activation of Unstrained C(O)-C Bond in Ketone Suzuki-Miyaura Coupling Reaction Enabled by Hydride-Transfer Strategy

Zhong, Jing,Zhou, Wuxin,Yan, Xufei,Xia, Ying,Xiang, Haifeng,Zhou, Xiangge

supporting information, p. 1372 - 1377 (2022/02/23)

Using Data Science To Guide Aryl Bromide Substrate Scope Analysis in a Ni/Photoredox-Catalyzed Cross-Coupling with Acetals as Alcohol-Derived Radical Sources

Doyle, Abigail G.,Gandhi, Shivaani S.,Jiang, Shutian,Kariofillis, Stavros K.,Martinez Alvarado, Jesus I.,?urański, Andrzej M.

supporting information, p. 1045 - 1055 (2022/01/19)

Synthesis of biaryl ketones and biaryl diketones via carbonylative Suzuki-Miyaura coupling reactions catalyzed by bridged bis(N-heterocyclic carbene)palladium(II) catalysts

-

Page/Page column 20; 22-26, (2021/12/23)

134-84-9 Process route

134-84-9 Upstream products

134-84-9 Downstream products

Relevant Products

Contact Now

Contact us

Maps

links