66104-23-2

  • Product NamePergolide mesylate salt
  • Molecular FormulaC19H26N2S.CH4O3S
  • Molecular Weight410.602
  • Purity99%
  • AppearanceWhite to off-white solid
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Product Details

Quick Details

  • CasNo: 66104-23-2
  • Molecular Formula: C19H26N2S.CH4O3S
  • Appearance: White to off-white solid
  • Purity: 99%

Excellent chemical plant bulk supply Pergolide mesylate salt 66104-23-2

  • Molecular Formula:CH4O3S*C19H26N2S
  • Molecular Weight:410.602
  • Appearance/Colour:White to off-white solid 
  • Melting Point:252-254 °C 
  • Boiling Point:491.3 °C at 760 mmHg 
  • PKA:pKa (66% DMF) 7.8(at 25℃) 
  • Flash Point:250.9 °C 
  • PSA:107.08000 
  • LogP:4.79380 

Pergolide mesylate salt(Cas 66104-23-2) Usage

Biochem/physiol Actions

Dopaminergic agonist; suppresses pituitary secretion of prolactin; anti-Parkinsonian agent.

Definition

ChEBI: A methanesulfonate salt obtained from pergolide by mixing eqimolar amount of pergolide and methanesulfonic acid. A dopamine D2 receptor agonist which also has D1 and D2 agonist properties, it i used in the management of Parkinson's disease, although it was withdrawn from the U.S. and Canadian markets in 2007 due to an increased risk of cardiac valve dysfunction.

InChI:InChI=1/C19H26N2S.CH4O3S/c1-3-7-21-11-13(12-22-2)8-16-15-5-4-6-17-19(15)14(10-20-17)9-18(16)21;1-5(2,3)4/h4-6,10,13,16,18,20H,3,7-9,11-12H2,1-2H3;1H3,(H,2,3,4)/t13-,16-,18-;/m1./s1

66104-23-2 Relevant articles

Development of a practical high-yield industrial synthesis of pergolide mesylate

Cabri, Walter,Roletto, Jacopo,Olmo, Sara,Fonte, Piera,Ghetti, Paolo,Songia, Simonetta,Mapelli, Elio,Alpegiani, Marco,Paissoni, Paolo

, p. 198 - 202 (2012/12/22)

The development of a high-yield and low ...

Decyanation of pergolide intermediate

-

, (2008/06/13)

The present invention provides a process...

6-N-Propyl-8-methoxymethyl or methylmercaptomethylergolines and related compounds

-

, (2008/06/13)

6-n-Propyl (ethyl or allyl)-8β-methoxy-(...

66104-23-2 Process route

(8β)-8-(hydroxymethyl)-D-ergoline-6-carbonitrile
108895-69-8

(8β)-8-(hydroxymethyl)-D-ergoline-6-carbonitrile

(8β)-D-ergoline-8-methanol
72821-81-9

(8β)-D-ergoline-8-methanol

pergolide mesylate
66104-23-2

pergolide mesylate

Conditions
Conditions Yield
With sodium hydroxide; In diethyl ether; water; ethylene glycol;
97.7%
pergolide
66104-22-1

pergolide

pergolide mesylate
66104-23-2

pergolide mesylate

Conditions
Conditions Yield
With methanesulfonic acid; In methanol;

66104-23-2 Upstream products

  • 66104-22-1
    66104-22-1

    pergolide

  • 108895-69-8
    108895-69-8

    (8β)-8-(hydroxymethyl)-D-ergoline-6-carbonitrile

  • 63719-21-1
    63719-21-1

    D-6-propyl-8β-hydroxymethylergoline

  • 75-75-2
    75-75-2

    methanesulfonic acid

;

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