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Product Details
Biochem/physiol Actions |
Dopaminergic agonist; suppresses pituitary secretion of prolactin; anti-Parkinsonian agent. |
Definition |
ChEBI: A methanesulfonate salt obtained from pergolide by mixing eqimolar amount of pergolide and methanesulfonic acid. A dopamine D2 receptor agonist which also has D1 and D2 agonist properties, it i used in the management of Parkinson's disease, although it was withdrawn from the U.S. and Canadian markets in 2007 due to an increased risk of cardiac valve dysfunction. |
InChI:InChI=1/C19H26N2S.CH4O3S/c1-3-7-21-11-13(12-22-2)8-16-15-5-4-6-17-19(15)14(10-20-17)9-18(16)21;1-5(2,3)4/h4-6,10,13,16,18,20H,3,7-9,11-12H2,1-2H3;1H3,(H,2,3,4)/t13-,16-,18-;/m1./s1
The development of a high-yield and low ...
The present invention provides a process...
6-n-Propyl (ethyl or allyl)-8β-methoxy-(...
(8β)-8-(hydroxymethyl)-D-ergoline-6-carbonitrile
(8β)-D-ergoline-8-methanol
pergolide mesylate
Conditions | Yield |
---|---|
With
sodium hydroxide;
In
diethyl ether; water; ethylene glycol;
|
97.7% |
pergolide
pergolide mesylate
Conditions | Yield |
---|---|
With
methanesulfonic acid;
In
methanol;
|
pergolide
(8β)-8-(hydroxymethyl)-D-ergoline-6-carbonitrile
D-6-propyl-8β-hydroxymethylergoline
methanesulfonic acid
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